Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network
Abstract Background Mutations in amyloid precursor protein (APP), presenilin 1 (PSEN1) and presenilin 2 (PSEN2) cause autosomal dominant forms of Alzheimer disease (ADAD).More than 280 pathogenic mutations have been reported in APP, PSEN1, and PSEN2.However, understanding of the basic biological mechanisms that drive the disease are limited.The Dom